Hibernation

We work with Dr. Sandy Martin at University of Colorado to study the genetic and cellular mechanisms that allow warm-blooded animals to survive repetitive cycles of profound metabolic suppression that occur during hibernation.

We apply next-generation genomic technology to characterize large-scale changes in the transcriptome and epigenome of the 13-lined ground squirrel, Ictidomys tridecemlineatus. Understanding how organs and cells protect against ischemia-reperfusion injury during hibernation could lead to novel strategies to treat trauma, stroke, and cardiac arrest.