Gulf War Illness & Toxicogenomics

We use the zebrafish (Danio rerio) as a model organism to study the effects of drugs and toxins. In particular, we study the response to pyridostigmine bromide (PB), a drug given to soldiers in the Gulf War of 1991 as a pretreatment against nerve agent exposure, to determine if its use is related to the chronic symptoms of Gulf War Illness. Techniques used in this research include RNA sequencing for transcriptome-wide studies and phenotypic assays to ensure that PB treatment dosages are clinically relevant. In addition, we use locomotion and neurobehavioral assays to understand the phenotypes potentially related to the neurocognitive symptoms of Gulf War Illness.